long break.

So hello.

I completely forgot that I have to complete the review paper's figures ideally by Monday. I should really do that tomorrow.

Here is a list of topics that I need to cover for my comprehensive:
Viral geneology and classification
properties of retroviruses with a focus on lentiviridae
HIV life cycle and various viral components.
HIV RT and all other RTs
Process of infection (cells infected, timing, damage etc)
The immune response
vaccine strategies
therapy strategies (biochemical and clinical) (general)
therapy strategies (RT specific)
Nucleic acid chemistry
Amino acid and protein chemistry
AIDS

that is all i can think of now.

so happy

Dunno about this blog. I can't say that it is doing much for me. That is why i haven't updated in so long. what do you think blog? should i cancel you?

I guess it just feels kind of funny writing to no one.

but then i don't really care to open it to the public either. I rather just talk to people.

As for the specific purpose of the blog, i don't know...i feel like i am better off just reading things and making notes of them. I don't really feel like I succeeded in making this a science-oriented blog. I don't have the patience to be consistent and write things in layman's language. But then again rewriting something is a really good way of testing one's understanding.

maybe i'll just keep this as an image blog. even then...i'm feeling pretty meh about all this. we'll see.

Newly discovered info on L234

Here is what I read today about L234 in HIV (the book, 2000). L234 is in the NNRTI binding pocket which is in the palm domain of p66 (roughly 10-15 angstroms away from the catalytic site (containing the aspartate residues). The NNRTI binding pocket is lipophilic and consists of three stranded beta sheets (beta 4, 7 and 8). What is of interest to me is the fact that eventhough L234 is indeed part of the wall of the binding pocket, its mutation has not been freqently associated with NNRTI resistance (except for the case of capravi???, which i wrote about awhile ago). Furthermore, it is associated with our inhibitor. But i guess i will learn more about that after the conference in L.A.

earrings

The Fresh Prince of Bel-Air really was an amazing show. we don't have shows like that anymore do we?

i have never been this comfortable with being alone.

this implies that i do not seek some else's comforting. I don't feel that i need it.

And this scares me because it, in turn, implies that no one can help me.

annd that is scary because it brings me to the conclusion that this is a helpless problem.


This is really at the interface of my rationality/reality and the realilty that is in my head and the ties that i can't shake off. but they are not supposed to be shaken off...but i am brainwashed.... i am paralysed here. in limbo.
what i know must be done is a physical impossibility for me.


no it is just too overwhelming. i can't sit down and think about it. If i thought other things were like staring into the sun... this is so much worse. this is paralysis. my brain will not go any further.

I am completely drained. and i will continue to be drained. this has already shaped so much of me. this can never be resolved.

home feel good

aaaaaaaaaaah.

i think i go sleep now.